abstract：:Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and significant health problem in the United States and worldwide. The mechanisms contributing to brain injury after SAH remain unclear. Traditionally, most in vivo research has heavily emphasized the basic mechanisms of SAH over the pat...

journal_title：Progress in neurobiology

authors： Chen S,Feng H,Sherchan P,Klebe D,Zhao G,Sun X,Zhang J,Tang J,Zhang JH

更新日期：2014-04-01 00:00:00

abstract：:Over the past two decades, the development of neuroimaging techniques has allowed the non-invasive investigation of neuroplastic changes associated with psychotherapeutic treatment. The aim of the present article is to present a systematic and critical review of longitudinal studies addressing the impact of psychother...

journal_title：Progress in neurobiology

authors： Barsaglini A,Sartori G,Benetti S,Pettersson-Yeo W,Mechelli A

更新日期：2014-03-01 00:00:00

abstract：:Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. Preconditioning has been observed in multiple organisms and can occur in the brain as well as other tissues. Extensive animal studies suggest that the brain can be preconditioned t...

journal_title：Progress in neurobiology

authors： Stetler RA,Leak RK,Gan Y,Li P,Zhang F,Hu X,Jing Z,Chen J,Zigmond MJ,Gao Y

更新日期：2014-03-01 00:00:00

abstract：:Because the treatment and management of neuropathic pain are extremely complicated, the characterization of novel analgesics and neuroprotectors with safe toxicological profiles is a crucial need to develop efficient therapies. Several investigations revealed that the natural neurosteroid allopregnanolone (AP) exerts ...

journal_title：Progress in neurobiology

authors： Patte-Mensah C,Meyer L,Taleb O,Mensah-Nyagan AG

更新日期：2014-02-01 00:00:00

abstract：:Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF) mRNA and protein in some regions of the brain, e.g. the basal lateral amygdala (BLA) but decreases in other regions such as the CA3 region of the hippocampus and dendritic spine density increases or decreases in line with these cha...

journal_title：Progress in neurobiology

authors： Bennett MR,Lagopoulos J

更新日期：2014-01-01 00:00:00

abstract：:Deep brain stimulation (DBS) has proven to be a successful therapeutic approach in several patients with movement disorders such as Parkinson's disease and dystonia. Hitherto its application was mainly restricted to advanced disease patients resistant to medication or with severe treatment side effects. However, there...

journal_title：Progress in neurobiology

authors： Woopen C,Pauls KA,Koy A,Moro E,Timmermann L

更新日期：2013-11-01 00:00:00

abstract：:Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental...

journal_title：Progress in neurobiology

authors： Barker RA,de Beaufort I

更新日期：2013-11-01 00:00:00

abstract：:As the genetics of neurodegenerative disease become better understood, opportunities for genetic susceptibility testing for at-risk individuals will increase. Such testing raises important ethical and practice issues related to test access, informed consent, risk estimation and communication, return of results, and po...

journal_title：Progress in neurobiology

authors： Roberts JS,Uhlmann WR

更新日期：2013-11-01 00:00:00

abstract：:Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease...

journal_title：Progress in neurobiology

authors： Subramaniam SR,Chesselet MF

更新日期：2013-07-01 00:00:00

abstract：:The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs). They belong to the group of CAG-repeat or polyglutamine diseases and share pathologically expanded and meiotically unstable glutamine-encod...

journal_title：Progress in neurobiology

authors： Rüb U,Schöls L,Paulson H,Auburger G,Kermer P,Jen JC,Seidel K,Korf HW,Deller T

更新日期：2013-05-01 00:00:00

abstract：:Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing present in all cortical areas. It is believed to contain a charac...

journal_title：Progress in neurobiology

authors： Feldmeyer D,Brecht M,Helmchen F,Petersen CC,Poulet JF,Staiger JF,Luhmann HJ,Schwarz C

更新日期：2013-04-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is one an intriguing set of nine neurodegenerative diseases caused by the expansion of a unstable trinucleotide CAG repeat where the repeat is located within the coding of the affected gene, i.e. the polyglutamine (polyQ) diseases. A gain-of-function mechanism for toxicity in SCA1,...

journal_title：Progress in neurobiology

authors： Orr HT

更新日期：2012-12-01 00:00:00

abstract：:Cardiovascular and neuroendocrine reactivity to acute stress are important predictors of health outcomes in non-pregnant populations. Greater magnitude and duration of physiological responses have been associated with increased risk of hypertensive disorders and diabetes, greater susceptibility to infectious illnesses...

journal_title：Progress in neurobiology

authors： Christian LM

更新日期：2012-11-01 00:00:00

abstract：:Aging and neurodegenerative conditions such as Alzheimer and Parkinson diseases are characterized by tissue and mitochondrial changes that compromise brain function. Alterations can include increased reactive oxygen species production and impaired antioxidant capacity with a consequent increase in oxidative damage, mi...

journal_title：Progress in neurobiology

authors： Marques-Aleixo I,Oliveira PJ,Moreira PI,Magalhães J,Ascensão A

更新日期：2012-11-01 00:00:00

abstract：:High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-band, transient burst-like phenomenon or steady-state. HFOs may be encountered under physiological or under pathological conditions (pHFO). Here we review the underlying mechanisms of oscillations, at the level of cells and netw...

journal_title：Progress in neurobiology

authors： Jefferys JG,Menendez de la Prida L,Wendling F,Bragin A,Avoli M,Timofeev I,Lopes da Silva FH

更新日期：2012-09-01 00:00:00

abstract：:As the population ages, the economic and societal impacts of neurodegenerative and neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive disorders are common and are linked to increased disability, high healthcare utilisation, cognitive decline and premature mortality. Considerab...

journal_title：Progress in neurobiology

authors： Naismith SL,Norrie LM,Mowszowski L,Hickie IB

更新日期：2012-07-01 00:00:00

abstract：:In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor neurons in cerebral cortex and lower motor neurons in brainstem and spinal cord. Accumulating evidence from recent studies suggests that th...

journal_title：Progress in neurobiology

authors： Cozzolino M,Carrì MT

更新日期：2012-05-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is the major intracellular proteolytic mechanism controlling the degradation of misfolded/abnormal proteins. A common hallmark in amyotrophic lateral sclerosis (ALS) and in other neurodegenerative disorders is the accumulation of misfolded/abnormal proteins into the damaged neuron...

journal_title：Progress in neurobiology

authors： Bendotti C,Marino M,Cheroni C,Fontana E,Crippa V,Poletti A,De Biasi S

更新日期：2012-05-01 00:00:00

abstract：:Synaptic transmission is a finely regulated mechanism of neuronal communication. The release of neurotransmitter at the synapse is not only the reflection of membrane depolarization events, but rather, is the summation of interactions between ion channels, G protein coupled receptors, second messengers, and the exocyt...

journal_title：Progress in neurobiology

authors： Betke KM,Wells CA,Hamm HE

更新日期：2012-03-01 00:00:00

abstract：:There are well-known sex differences in the epidemiology and etiopathology of alcohol dependence. Male gender is a crucial risk factor for the onset of alcohol addiction. A directly modifying role of testosterone in alcohol addiction-related behavior is well established. Sex hormones exert both permanent (organization...

journal_title：Progress in neurobiology

authors： Lenz B,Müller CP,Stoessel C,Sperling W,Biermann T,Hillemacher T,Bleich S,Kornhuber J

更新日期：2012-01-01 00:00:00

abstract：:This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene blue in vivo. These mechanisms have important implications as a new neurobiological approach to improve normal memory and to treat memory impairment and neurodegeneration associated with mitocho...

journal_title：Progress in neurobiology

authors： Rojas JC,Bruchey AK,Gonzalez-Lima F

更新日期：2012-01-01 00:00:00

abstract：:Rapid developments in medical neuroimaging have made it possible to reconstruct the trajectory of Alzheimer's disease (AD) as it spreads through the living brain. The current review focuses on the progressive signature of brain changes throughout the different stages of AD. We integrate recent findings on changes in c...

journal_title：Progress in neurobiology

authors： Ewers M,Frisoni GB,Teipel SJ,Grinberg LT,Amaro E Jr,Heinsen H,Thompson PM,Hampel H

更新日期：2011-12-01 00:00:00

abstract：:The nervous system and the gastrointestinal (GI) tract share several common features including reciprocal interconnections and several neurotransmitters and peptides known as gut peptides, neuropeptides or hormones. The processes of digestion, secretion of digestive enzymes and then absorption are regulated by the neu...

journal_title：Progress in neurobiology

authors： Mourad FH,Saadé NE

更新日期：2011-10-01 00:00:00

abstract：:Most spiking neurons are divided into functional compartments: a dendritic input region, a soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of action potentials, and distal arborizations and terminals carrying the output synapses. The axon trunk and lower order branches ar...

journal_title：Progress in neurobiology

authors： Bucher D,Goaillard JM

更新日期：2011-09-01 00:00:00

abstract：:An understanding of how axons elongate is needed to develop rational strategies to treat neurological diseases and nerve injury. Growth cone-mediated neuronal elongation is currently viewed as occurring through cytoskeletal dynamics involving the polymerization of actin and tubulin subunits at the tip of the axon. How...

journal_title：Progress in neurobiology

authors： Suter DM,Miller KE

更新日期：2011-07-01 00:00:00

abstract：:At the psychological level, the notion that emotional events may be better remembered is a long accepted view. Its translation into neurobiological mechanisms has led to the proposal of the 'emotional tag' concept, according to which, the activation of the amygdala by emotionality would result in modulation of neural ...

journal_title：Progress in neurobiology

authors： Bergado JA,Lucas M,Richter-Levin G

更新日期：2011-06-01 00:00:00

abstract：:Aging of the human brain is associated with "normal" functional, structural, and molecular changes that underlie alterations in cognition, memory, mood and motor function, amongst other processes. Normal aging also imposes a robust constraint on the onset of many neurological diseases, ranging from late onset neurodeg...

journal_title：Progress in neurobiology

authors： Glorioso C,Sibille E

更新日期：2011-02-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) constitute a unique population of glia that accompany and ensheath the primary olfactory axons. They are thought to be critical for spontaneous growth of olfactory axons within the developing and adult olfactory nervous system, and have recently emerged as potential candidates for ce...

journal_title：Progress in neurobiology

authors： Su Z,He C

更新日期：2010-12-01 00:00:00

abstract：:The scientific understanding of preproglucagon derived peptides has provided people with type 2 diabetes with two novel classes of glucose lowering agents, the dipeptidyl peptidase IV (DPP-IV) inhibitors and GLP-1 receptor agonists. For the scientists, the novel GLP-1 agonists, and DPP-IV inhibitors have evolved as us...

journal_title：Progress in neurobiology

authors： Vrang N,Larsen PJ

更新日期：2010-11-01 00:00:00

abstract：:Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila due to rapid developments in molecular genetics approaches that overcome the difficulties caused by the small size of the fly. In addition we have genome-wide information on genes involved in peptide signaling, and growing pools of p...

journal_title：Progress in neurobiology

authors： Nässel DR,Winther AM

更新日期：2010-09-01 00:00:00

abstract：:The cloning of K(Ca)2 channels revealed three subtypes, with each displaying distinct but partially overlapping expression distributions in the mammalian CNS and periphery. Activation of K(Ca)2 channels leads to membrane hyperpolarization and inhibition of action potential firing. Block of K(Ca)2 channels has been sug...

journal_title：Progress in neurobiology

authors： Weatherall KL,Goodchild SJ,Jane DE,Marrion NV

更新日期：2010-07-01 00:00:00

abstract：:Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that have expanded their ...

journal_title：Progress in neurobiology

authors： Griffin DE

更新日期：2010-06-01 00:00:00

abstract：:Japanese encephalitis (JE) is one of the most important endemic encephalitis in the world especially in Eastern and Southeastern Asia. JE affects over 50,000 patients and results in 15,000 deaths annually. JE virus is a single stranded positive sense RNA virus belonging to family flaviviridae. JE virus is transmitted ...

journal_title：Progress in neurobiology

authors： Misra UK,Kalita J

更新日期：2010-06-01 00:00:00

abstract：:The extracellular parasite Trypanosoma brucei causes human African trypanosomiasis (HAT), also known as sleeping sickness. Trypanosomes are transmitted by tsetse flies and HAT occurs in foci in sub-Saharan Africa. The disease, which is invariably lethal if untreated, evolves in a first hemo-lymphatic stage, progressin...

journal_title：Progress in neurobiology

authors： Kristensson K,Nygård M,Bertini G,Bentivoglio M

更新日期：2010-06-01 00:00:00

abstract：:Brain damage can sometimes render a patient persistently unresponsive and yet apparently awake, admitting the possibility that the absence of overt voluntary behaviour might conceal a retained capacity for covert cognition. When given instructions to perform a cognitive task, a minority of patients in such a so-called...

journal_title：Progress in neurobiology

authors： Nachev P,Hacker PM

更新日期：2010-05-01 00:00:00

abstract：:Cells in the nervous system can respond to different kinds of stress, e.g. injury, with production and release of inflammatory molecules, including cytokines. One of the most important proinflammatory cytokines is interleukin-1, affecting most organs of the body. The high constitutive expression of interleukin-1 in th...

journal_title：Progress in neurobiology

authors： Spulber S,Schultzberg M

更新日期：2010-02-09 00:00:00

abstract：:Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of neurodegenerative disorders (NDs) by stimulating, responding to and interacting with target sites to induce physiological responses while minimizing side-effects. C...

journal_title：Progress in neurobiology

authors： Modi G,Pillay V,Choonara YE,Ndesendo VM,du Toit LC,Naidoo D

更新日期：2009-08-01 00:00:00

abstract：:Despite huge improvements in neurobiological approaches for investigating the functional properties of neurotransmitter receptors and ion channels, many difficulties are still encountered when focusing on the human brain. Electrophysiological studies aimed at performing direct determinations on human nervous tissue ar...

journal_title：Progress in neurobiology

authors： Eusebi F,Palma E,Amici M,Miledi R

更新日期：2009-05-01 00:00:00

abstract：:Classically, the olfactory and vomeronasal pathways are thought to run in parallel non-overlapping axes in the forebrain subserving different functions. The olfactory and vomeronasal epithelia project to the main and accessory olfactory bulbs (primary projections), which in turn project to different areas of the telen...

journal_title：Progress in neurobiology

authors： Martinez-Marcos A

更新日期：2009-01-12 00:00:00

abstract：:Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem ...

journal_title：Progress in neurobiology

authors： Bender RA,Baram TZ

更新日期：2008-11-01 00:00:00